Folder 7 - Next Generation Sequencing
The most recent developments in genetic technology relevant to the uses of forensic genetics in support of investigations and prosecutions is ‘Next Generation’ or Multiple Parallel’ Sequencing. This advance makes it possible to derive – in one reaction – a much larger volume of genetic information (including ‘medically relevant’ information) from a biological sample, than had previously been possible. Whilst this increased information may be useful in principle, the enlargement of scope raises issues of what such information it is generally permissible for investigators to access, what uses may be made of it, what obligations then exist about securing its confidentiality or its disclosure to relevant others, etc., etc. The papers collected in this folder provide an introduction to these developing issues and questions.
Ram (2005) DNA By the Entirety
Budowle et al (2005) Forensic analysis of the mitochondrial coding region and association to disease
Szibor (2005) The HumARA genotype is linked to spinal and bulbar muscular dystrophy and some further disease risks and should no longer be used as a DNA marker for forensic purposes
Bandelt et al. (2008) The Brave New Era of Human Genetic Testing
Elger et al. (2009) Sudden death: ethical and legal problems of post-mortem forensic genetic testing for hereditary cardiac diseases
Fullerton and Lee (2011) Secondary uses and the governance of de-identified data: Lessons from the human genome diversity panel
Wienroth et al. (2014) Technological Innovations in Forensic Genetics: Social, Legal and Ethical Aspects
Nuffield Council on Bioethics (2015) The Collection, Linking and Use of Data in Biomedical Research and Health Care
Parson (2016) Massively parallel sequencing of forensic STRs: Considerations of the DNA commission of the International Society for Forensic Genetics (ISFG) on minimal nomenclature requirements